Abstract

REACTIVATION AND RESOLUTION IN SHINGLES: A COMPREHENSIVE REVIEW OF HERPES ZOSTER

K. Arunkumar*, P. Nandhitha, T. Sampath Kumar, C. Jothimanivannan, R. Thirumalai and K. Haripriya

Abstract

Herpes zoster, commonly known as shingles, is a viral infection caused by the reactivation of the varicella-zoster virus, the same virus responsible for chickenpox. It primarily affects older adults or individuals with weakened immune systems. The disease is characterized by a painful, blistering skin rash, often localized to a specific dermatome. This review focuses on the epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of herpes zoster. Additionally, the article discusses complications, such as postherpetic neuralgia, and the impact of vaccination in preventing the disease. Recent advancements in antiviral therapies and immune response modulation are also explored, providing a comprehensive overview of current strategies in managing and preventing shingles.

Keywords: Herpes Zoster, Shingles, Treatment, Diagnosis, History, mechanism.