Abstract

TOPICAL PRONIOSOMAL GEL: A COMPREHENSIVE REVIEW

Himanshu* and Ashish Saini

Abstract

Offering several benefits over conventional systemic drug delivery methods, topical medication administration has long been acknowledged as a successful way for delivering therapeutic substances straight to the site of action.[1] Among these advantages are avoidance of first-pass metabolism, better patient compliance, localised therapy with fewer overall adverse effects, and simplicity of use. But because of its unusual structure—tightly packed corneocytes buried in a lipid matrix the stratum corneum, the outermost layer of the skin, presents a significant barrier to effective medication absorption.[2] Many topical therapies are limited by this very strong biological barrier, which prevents most therapeutic molecules, especially those with a large molecular weight or hydrophilic character, from passing.[3] Developing new medication delivery methods has been a major focus to get past the restrictions of the skin barrier. Among them, vesicular systems like liposomes, niosomes, ethosomes, and transfersomes have demonstrated an amazing ability to improve medication penetration of the skin.[4] Particularly, niosomes, non-ionic surfactant-based vesicles, have attracted interest for their capacity to increase drug stability, provide focused drug administration, and encapsulate both hydrophilic and lipophilic pharmaceuticals. Although niosomal dispersions have advantages, their limited general use is hampered by stability problems, including aggregation, fusion, and drug leakage during storage.[5]

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