Abstract

SYNERGISTIC NAIL LACQUER FORMULATION OF CISSUS QUADRANGULARIS AND ITRACONAZOLE FOR ENHANCED ONYCHOMYCOSIS MANAGEMENT

*Ankita Ingale, Tejaswini Jagtap, Pravin Gade, Janhavi Shinde, Mukesh Kote and Pruthvirani Sakhare

Abstract

Objective: This study aimed to create an aesthetic nail lacquer containing a natural antifungal agent from the Cissus quadrangularis plant with itraconazole to treat fungal nail infections (onychomycosis). Methodology: The researchers extracted antifungal compounds from the Cissus quadrangularis plant and evaluated their effectiveness against Candida albicans, a common fungus causing onychomycosis. We formulated a nail lacquer using this extract in combination with antifungal agent itraconazole. Results: The study found that the Cissus quadrangularis extract exhibited enhanced antifungal activity with itraconazole. The formulated nail lacquer demonstrated excellent physical properties, including aesthetically pleasing color, glossiness and faster drying time. Moreover, the nail polish showed high permeability through goat nail, indicating its potential effectiveness in treating onychomycosis. Conclusion: This study suggests that a nail lacquer containing Cissus quadrangularis extract with itraconazole could be a promising alternative for treating onychomycosis, offering a potentially safer and more effective solution than existing treatments.

Keywords: Nail Lacquer, Cissus quadragularis Extract, Itraconazole, Onychomycosis, Candida Albicans.