Abstract

ANTIDIABETIC ACTIVITY OF HERBAL DRUG

Ketaki Ingawale*

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Abstract

Diabetes mellitus is a chronic disease characterized by elevated blood glucose levels, disturbances in the carbohydrate, fat and protein metabolism. Diabetes mellitus is considered to be a serious issue in many countries and traditional methods using medicinal plants to control diabetes is gaining momentum. The synthetic hypoglycemic agent/s does produce serious side effects and whereas drug derived from medicinal plants are frequently consider being safe & cost effective. Herbal preparations are used to treat diabetes, as an alternative therapy but their reported hypoglycemic effects are multifarious. Hence there is a need to search for safer hypoglycemic agent/s from plant origin. The present study was conducted on plant jasminum sambac to evaluate its antidiabetic activity. The herbal preparations were made with aqueous and organic solvents. Ethanolic and water extract prepared and monitored the effects on oral administration of different doses (250 mg/kg) and (500 mg/kg) of each extract in Streptozotocine induced diabetic Sprague dawley adult male rats. Glibenclamide (0.25 mg/kg) were used as positive control drug. results indicate that the root of jasminum sambac have anti-diabetic activity.

Keywords: Diabetes mellitus, Hypoglycemia, Streptozotocine, Histopathology, Hyperglycemia.