Abstract

DEVELOPMENT OF GASTRORETENTIVE FLOATING TABLETS OF OFLOXACIN USING FENUGREEK MUCILAGE AS A NATURAL POLYMER

Mr. Aniket Bhadake*, Prof. Nandini Patil and Dr. Megha Salve

Abstract

Ofloxacin is classified as a second-generation fluoroquinolone and is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. For dose forms that stay in the stomach longer than traditional dosage forms, the capacity to prolong and regulate the emptying time is a major asset. The process by which dose forms are gastrically emptied varies greatly. Designing controlled release systems for improved absorption and increased bioavailability presents a number of challenges. To solve the issue of traditional dose forms of effervescent floating tablets of loxacin were created in six distinct formulas (F1 through F6) using sodium bicarbonate as an effervescent ingredient and various polymer grades. Numerous physical metrics, buoyancy studies, dissolving factors, and drug release processes were assessed for the formulations. Ofloxacin’s slow and maximal drug release over a 24-hour period was provided by the F6 formulation, which also displayed good physical properties and the highest dissolution profile similarity to the marketed product. To assess release mechanisms and kinetics, various kinetic models were applied to drug release data.

Keywords: Novel Drug Delivery System, floating Drug Delivery System, Bioavailability.