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Abstract

PHYTOCHEMICAL SCREENING AND PHARMACOLOGICAL EVALUATION OF ANTICANCER ACTIVITY OF METHANOLIC EXTRACT OF MAYTENUS EMARGINATA (WILLD) IN RATS

Harshachandra*, Sura Ramya Sri and Ketan Hatware

Abstract

Cancer is one of the most serious health problems that affect the duration and quality of the individual’s life. Enormous efforts are invested to cope with this problem, but unfortunately limited success has ever been achieved with most of the therapeutic strategies. These efforts are usually complicated with the need for well experienced surgeons, lack of specificity and high cost, as well as being usually accompanied with a wide range of side effects. As the conventional therapeutic strategies fail to fulfill the major requirements for a successful cancer therapy, the use of naturally developed anticancer agents has evolved as an alternative safe, low-cost and convenient one. Therefore, the use of plant extracts with potential anticancer therapeutic effects might be particularly significant, especially in Palestine, which is rich in thousands of plant species known for their medical uses. Moreover, the lack of expertise, the scares economical resources and the complicated political situation in Palestine don’t allow the application of sophisticated surgical, chemo- and radio-therapies to cure cancer. Therefore, the current study, investigates the effect of crude methanolic extracts from Maytenus emarginata, Fig on cell lines derived from different human tissue origins (Hep3b: Hepatocellular carcinoma; Hela: cervical epithelial cancer; and A549: human lung adrenal cancer).The results showed a concentration-dependent reduction in the final number of cancer cells in consequence to treatment with the aforementioned methanolic extracts. Two kinds of anticancer effects were evaluated and found tocontribute to this reduction: the antiproliferation effect (decreased number of metabolically active cells) and cytotoxicity (decreased number of live cells).This extracts possess both of the effects with various degrees. Maytenus emarginata possess the strongest and most profound effects on the three cell lines, mainly by induction of cell death.Further studies are needed to assess the active ingredients of Maytenus emarginata, involved in the antiproliferative or cytotoxic effects of these plants. These studies must involve the establishment of in vivo animal models and the application of more efficient extraction and fractionation techniques.

Keywords: Anti-cancer, Maytenus Emarginata, In-vitro, Phytochemistry, Pharmacological Evaluation.


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