Abstract

AIM: PREPARATION AND EVALUATION OF SEMI-SYNTHETIC ANTI-ACNE GEL

Balkrishna D. Tiwari, Shruti S. Garad, Trupti A. Kale*, Mrunali R. Kale and Komal D. Kodag

Abstract

Acne is most common skin problem mainly occurs in teenagers during adolescent stage. It can be a very unpleasant appearance of skin due to acne which primarily looks like red patches filled with puss due to inflammation caused by bacteria. The main causative bacteria for acne is Propionibacterium and the acne is well known as acne vulgaris.[1] There are various synthetic pharmaceutical products are present in market to treat this problem but the continuous use of chemical based formulation can cause skin damage over a period of time. To avoid any other skin problems, modern generation is turning towards using herbal based pharmaceuticals which are highly effective as well as gives very less side effects. This research is aimed to formulate semi synthetic anti acne gel in combination with tomato extract[2],[3], Aloe vera and honey which gives significant result in acne treatment. This gel formulated using different concentrations of aloe vera, tomato extract and honey in batches F1, F2 and F3. The gel phase of formulation is prepared by using Carbopol-940 as gelling agent, Triethanolamine as pH stabilizer, Glycerol as humectant and EDTA as a stabilizer.[4] The evaluation test like Stability, Spreadability, Washability, pH, Antimicrobial activity are studied, the test results shows an impactful gel formulation which could be a better alternative for treatment of acne. The prepared gel is stored under normal room temperature and shown positive results.[6]

Keywords: Herbal gel, Acne vulgaris, Tomato, Aloe vera, Honey.