WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

SYNTHESIS OF 1,3,5-TRIAZINE BASED PYRIMIDINES AS POTENT ANTI-BACTERIAL AND ANTI-FUNGAL AGENTS

Anupama and *Bhawani Singh

Abstract

Objectives: Pyrimidines and 1,3,5-triazines play an important role in many biological processes. 2,4,6-trichloro-1,3,5-triazine (TCT) provides a good opportunity to a chemist in the synthesis of its various derivatives by the replacement of its chlorine atom with bioactive pharmacophores at three different temperatures. Hence, present work was carried out keeping in mind that combination or addition of two or more pharmacophores may enhance the biological activities with wide spectrum of their pharmacological profile. Methods: Chalcone derivatives of [(E)-1-(4-(4,6-bis(pyrimidine-2-ylamino)-1,3,5-triazine- 2-ylamino) phenyl)-3(pyridine-2-yl)prop-2-en-1-one & (E)-3- (pyridine-2-yl)-1-(4-(4-(4-(E)-3-(pyridine-2-yl)acryloyl)phenylamino)- 6-(pyrimdine-2-ylamino)-1,3,5-triazine-2-ylamino)phenyl)prop-2-en- 1-one] were prepared to explore to provide an easy one pot synthesis with urea, thiourea and guanidine to furnish pyrimidine analogues. All the compounds synthesized were characterized elemental analysis and IR, 1H NMR, MS data. Conclusion: Compound 2 and 8 has been found to possess good anti-bacterial and anti-fungal activity.

Keywords: Chalcones, s-triazines, urea, thiourea, guanidine nitrate, pyrimidines, antibacterial and anti-fungal activities.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More