Abstract

SYNTHESIS OF 1,3,5-TRIAZINE BASED PYRIMIDINES AS POTENT ANTI-BACTERIAL AND ANTI-FUNGAL AGENTS

Anupama and *Bhawani Singh

Abstract

Objectives: Pyrimidines and 1,3,5-triazines play an important role in many biological processes. 2,4,6-trichloro-1,3,5-triazine (TCT) provides a good opportunity to a chemist in the synthesis of its various derivatives by the replacement of its chlorine atom with bioactive pharmacophores at three different temperatures. Hence, present work was carried out keeping in mind that combination or addition of two or more pharmacophores may enhance the biological activities with wide spectrum of their pharmacological profile. Methods: Chalcone derivatives of [(E)-1-(4-(4,6-bis(pyrimidine-2-ylamino)-1,3,5-triazine- 2-ylamino) phenyl)-3(pyridine-2-yl)prop-2-en-1-one & (E)-3- (pyridine-2-yl)-1-(4-(4-(4-(E)-3-(pyridine-2-yl)acryloyl)phenylamino)- 6-(pyrimdine-2-ylamino)-1,3,5-triazine-2-ylamino)phenyl)prop-2-en- 1-one] were prepared to explore to provide an easy one pot synthesis with urea, thiourea and guanidine to furnish pyrimidine analogues. All the compounds synthesized were characterized elemental analysis and IR, 1H NMR, MS data. Conclusion: Compound 2 and 8 has been found to possess good anti-bacterial and anti-fungal activity.

Keywords: Chalcones, s-triazines, urea, thiourea, guanidine nitrate, pyrimidines, antibacterial and anti-fungal activities.