Abstract

FORMULATION & EVALUATION OF MOUTH DISSOLVING TABLETS OF DIMENHYDRINATE USING COPROCESSED SUPERDISINTEGRANTS

Aman*, Dr. Rajesh Sharma, Dr. Gurpreet Singh, Dr. Jeyabalan G. and Dr. Praveen Goyal

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Abstract

This research involves preparation of mouth dissolving tablets of Dimenhydrinate by direct compression method using various concentrations of co-processed superdisintegrants i.e. Sodium starch glycolate and crospovidone prepared by different methods viz. Microwave and Lyophilization. SSG and crospovidone used in different ratio (1:1, 1:2, 1:3, 2:1, 2:2, 2:3, 3:1, 3:2 and 3:3). The tablets were evaluated for parameters like thickness, hardness, friability, In vitro & In vivo disintegration time, wetting time, water absorption ratio, % drug content and In vitro drug release studies. Based on the results, formulation containing 6% superdisintegrants in combination (CP:SSG = 3:3) (DL-9) was identified as ideal and better formulation among all formulations developed for Dimenhydrinate tablets. In vitro release of optimized formulation of Dimenhydrinate Mouth dissolving tablets (DL-9) prepared by lyophilized technology was found to be 99.98% drug release within 15minutes and in-vitro disintegration time being ranges between 33- 35sec. Though formulation DM-9 also showed good release (96.83%) prepared by microwave technology but since the release rate & disintegration profile is comparatively poor hence it is not selected. Optimized formulation DL-9 showed very good stability profile. From this observation it was concluded that the formulated tablets of Dimenhydrinate (DL-9) were superior, economic and effective in achieving patient compliance.

Keywords: Dimenhydrinate superdisintegrants crospovidone Lyophilization.