Abstract

IN SILICO DOCKING, ADMET PREDICTION AND BIOLOGICAL ACTIVITY EVALUATION OF TRIAZOLOAZETIDIN-2-ONES

Shaik Ayesha* and Bijankari Balaji

.

Abstract

A series of thirteen novel azetidinones T1-13 were synthesized by cyclocondensation of various Schiff bases of aldehydes with 1,2,4- triazole. Schiff's bases preparing from 1,2,4 triazole moiety by reacting the hydrazide of the parent compound with different aromatic or heterocyclic aldehydes under acidic conditions in ethanol and cyclocondensation of Schiff's bases with chloracetyl chloride in the presence of triethylamine and dioxane resulted in the formation of corresponding spectra. The synthesized compounds were evaluated for antibacterial and antifungal activities by disk diffusion method and also evaluated for anti-tubercular activity,

Keywords: Molecular docking studies, ADMET prediction, Antitubercular activity, Azetidinones, Antimicrobial activity.