Abstract

PHARMACOLOGICAL SCREENING OF TECTONA GRANDIS BARK FOR MEMORY ENHANCING ACTIVITY IN RAT MODEL

Sakshi A. Jadhav*, Dr. Abhijit V. Shrirao, Deepak S. Mohale, Dr. Nitin Kochar and Dr. A. V. Chandewar

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Abstract

Objective: This study was carried out to evaluate the memoryenhancing effect of Tectona grandis (teak) extract in rats. Method: Memory loss was induced in rats using scopolamine, a drug known to cause temporary amnesia. The rats were divided into different groups and treated with either Tectona grandis extract, a standard memoryenhancing drug. Their memory and learning were tested using methods like the Elevated Plus Maze and Morris Water Maze. The results showed that rats treated with Tectona grandis extract performed better in memory tests compared to the scopolamine group. Conclusion: This suggests that the extract may help improve memory, possibly due to its antioxidant and brain-protective properties. These findings support the traditional use of Tectona grandis for improving brain function.

Keywords: Tectona grandis, Scopolamine, Alzheimer’s Disease, Memory impairment, Acetylcholinesterase.