Abstract

THERAPEUTICS MONITORING AND CHARACTERISTIC APPLICATION OF DRUG USED IN HYPERTENSIVE PATIENTS

Syed Azhar Ullah Quadri*, Hajera Hafeez, Mohd. Ateeq Ur Rehman, Mohammed Zubair Ahmed, Syed Fayyazuddin, Md. Ismail zubair, Pawan Kumar, Mohammed Majid Iqbal

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Abstract

The main objective of the study is to assess drug use pattern of antihypertensive medications in hypertensive patients. It is a prospective study conducted in the Tertiary care hospital, for the period of 8 months from June 2024 to January 2025. About 500 prescriptions of patients visiting Hospital with an antihypertensive prescription were enrolled for the study. Drug use patterns of different modules of antihypertensive medications were analyzed from separate prescriptions. A total of 500 patients were included in this study, among which 281 were male 56.2% & 219 43.8% were female. In 500 patients, 133 patients were treated with monotherapy. In that 42.1% of patients were treated with amlodipine, 28.57% of patients were treated with losartan. In combination therapy most commonly used was double therapy 42.8% followed by triple therapy 24.2%. Calcium Channel Blockers 56.2% was most prescribed class of drug followed by Angiotensin Receptor Blockers. In our study the final conclusion of the study reveals that calcium channel blockers as most prescribed class of antihypertensive and Amlodipine was the most prescribed antihypertensive. In our study, most of the patients were treated with combination therapy in that double drug therapy was most common. There is a chance of various medication errors, development of adverse drug reaction as majority 290 of patients belong to age above 60 and chances of getting error also increases as combination therapy is most used. Therefore, close monitoring is required for such patients. During our discussion with patients we suggested for Lifestyle changes, it can help lower high blood pressure. Include, eating a healthy, low-salt diet, losing weight, being physically active and quitting tobacco & Alcohol.

Keywords: Angiotensin Receptor Blockers, Calcium Channel Blockers, Drug Utilization Study, Hypertension & Hospital.