Abstract

ENHANCING THE BIOAVAILABILITY OF NEEM-BASED HERBAL TONICS: A STUDY ON EXTRACTION AND DELIVERY METHODS

Abdul Rehman Shaikh*, Sakinabanu Shaikh, Yash Salte, Saufee Jamadar, Samiksha Mhatre and Priyanka Varade

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Abstract

Background: Neem oil is particularly beneficial for hair care, treating issues like dandruff, dryness, and scalp infections. Despite its potential, scientific evaluation of its microscopic, phytochemical, and antioxidant properties is necessary to establish its efficacy in hair care formulations. Objective: The purpose of this study is to create and assess an herbal hair tonic that is beneficial for the health of the scalp and hair by utilizing neem seed extract and other naturally occurring compounds. Method: Microscopic staining identified lignified xylem and cuticles. Neem oil was extracted via cold-pressing and Soxhlet (hexane). Nimbolide and azadirachtin were compared for antioxidant activity using free radical scavenging. Result and Discussion: Microscopic analysis confirmed lignified xylem and cuticle layers. Soxhlet extraction yielded clearer oil, while cold-pressing produced high-quality virgin oil for cosmetics. Antioxidant tests ranked nimbolide > azadirachtin > ascorbate. Neem also showed potential in cancer management by regulating tumor suppressor genes and apoptosis. Conclusion: Neem oil has anti-dandruff, antioxidant, and hair-growth properties, making it a promising natural hair treatment. Further research can enhance its efficacy in formulations.

Keywords: Neem Seed, Cold-pressing, Antioxidant activity, Soxhlet extraction, Dandruff control, Free radical scavenging, Microscopic analysis, Phytochemical evaluation.