Abstract

FORMULATION AND EVALUATION OF LEMONGRASS (CYMBOPOGON CITRATUS) DERIVED MOSQUITO REPELLENT ACTION BY TRANSDERMAL DRUG DELIVERY

Balkrishna Tiwari, Garad Shruti Satish, *Kasturi Sanjana Amarnath and Kamuni Shreya Shriniwas

Abstract

Mosquito-borne diseases like malaria, dengue, chikungunya, filariasis, and Zika remain major health concerns, especially in tropical regions. While synthetic repellents are effective, they often cause skin irritation. This study explores herbal transdermal patch using lemongrass (Cymbopogon citratus) and ajwain (Trachyspermum ammi) extracts, known for their repellent properties. The patch was formulated with HPMC, CMC, PEG 400, lavender oil, and ethanol. It was evaluated for weight, thickness, folding endurance, moisture content, pH, and more. Results showed good physical stability, skin compatibility, and strong mosquito repellent activity in net cage tests. Stability studies confirmed long-term effectiveness. Overall, the herbal patch provides a safe, natural, and skin-friendly alternative to chemical repellents, offering prolonged protection against mosquito-borne diseases.

Keywords: Mosquito-borne diseases, patch, Mosquito repellents, Transdermal drug delivery system, Transdermal patch, Lemongrass.