Abstract

DISCOVERY OF ANTIMICROBIAL PEPTIDES IN URINARY TRACT INFECTIONS

Suraj Mashale, *Abhilasha Korke and Samruddhi Kulkarni

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Abstract

In the innate immune system, antimicrobial peptides (AMPs) are essential for providing first-line protection against microbial pathogens. In urinary tract infections (UTIs), AMPs can act as biomarkers and substitute medications, reducing mortality from multidrug-resistant organisms. AMPs have been shown to be relevant in UTIs, and US Food and Drug Administration-approved AMP medications are being used in clinical settings; nevertheless, little is known regarding their regulation, mechanism of action, and modification status. Just a small percentage of sequences projected to have potential AMP activity based on known AMP properties have been confirmed. A thorough, disease-specific understanding of the innate immune system and the creation of customized AMP biomarkers and antibiotics would be made easier by the elucidation of the global profile of AMPs in the bladder, kidney, and urine under UTI circumstances. This focuses on an all-encompassing approach to global characterization and validation of AMPs in UTIs that includes proteomics, prediction algorithms, and AMP data repositories for both healthy people and UTI patients.

Keywords: Antimicrobial peptides, Urinary tract infection, Forecasting algorithm, Proteomics, Mass spectrometry.