Abstract

FORMULATION AND EVALUATION OF AZITHROMYCIN LOADED IN LIPOSOMAL SUSPENSION

*B.D. Tiwari, Dipali N. Devkar, Avinash S. Diddi and Shubham J. Gaikwad

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Abstract

The current investigation focuses on creating and assessing azithromycin-loaded liposomes aimed at enhancing the therapeutic efficacy and bioavailability of the drug. The broad-spectrum macrolide antibiotic azithromycin has weak tissue penetration and low oral bioavailability. Liposomal encapsulation offers a promising method to get around these restrictions by enhancing medication stability, longterm release, and targeted delivery. In this study, phosphatidylcholine and cholesterol were used as the principal ingredients in liposomes made via the thin film hydration method components. The formulations were optimized by varying lipid-to-drug ratios and evaluated for key parameters including particle size, polydispersity index (PDI), zeta potential, drug release profile in vitro, and encapsulation effectiveness. The optimized showed a zeta of 185.6 nm, a PDI of 0.224, and a mean particle size of 185.6 nm. potential of 32.4 mV, indicating good stability. Encapsulation efficiency was found to be 78.5%, and in vitro release studies demonstrated sustained drug release over 24 hours. These findings suggest that liposomal delivery of azithromycin could offer significant benefits in terms of improved pharmacokinetics and reduced dosing frequency, thus making it a viable candidate for further in vivo studies and clinical application.

Keywords: Azithromycin-loaded liposomes, Liposomal delivery systems, Antibiotic encapsulation Nanomedicine, Drug delivery systems.