Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME THIAZOLIDINONE-QUINOLINE DERIVATIVE

Gaurav Desai, Ashish Asrondkar, Vrushali Patil*, Anil Bobade, Abhay Chowdhary

Abstract

N'-[2-(quinolin-8-yloxy) acetyl] benzohydrazide (2) obtained from 8- hydrozy quinoline (1) was converted to the corresponding 2-(quinolin- 8-yloxy) acetohydrazide (3) by treatment with hydrazine hydrate. The basic treatment of (3) and substituted benzaldehyde yielded the corresponding schiff base derivatives (4a-e). The synthesis of N-(4- oxo-2- substituted phenyl-1, 3-thiazolidin-3-yl)-2-(quinolin-8-yloxy) acetamide (5a-e) was performed from the reaction of (4) with thioglycolic acid in basic media. The newly synthesized compounds were characterized by elemental analyses, IR, 1H-NMR, and mass spectra. The antimicrobial activity study revealed that newly synthesized compounds dose not showed moderate activity against a variety of microorganisms (E. coli, S. aureus, C. albicans).

Keywords: 8-hydroxy Quinoline, schiff base, 1,3-thiazolidin-3-yl, antimicrobial activity.