Abstract

REVIEW ON VARIOUS TECHNIQUES OF SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS WITH SPECIAL EMPHASIS ON CO-CRYSTALLIZATION

Aishwarya R. Mohite*, Dr. Nagesh C., Sushant L. Pawashe and Ravikiran M. Kadolkar

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Abstract

The effectiveness and bioavailability of pharmacological substances are significantly influenced by solubility, especially for medications that are poorly soluble in water. Particle size reduction, salt generation, and solid dispersions are some of the methods that have been developed to improve solubility in order to address this difficulty. To increase solubility and dissolution rates without chemically altering the active pharmaceutical ingredient (API), co-crystallization has shown to be a very successful technique. One or more co-formers and the API are joined by non-covalent bonds such hydrogen bonds to produce cocrystals. Solubility, stability, and bioavailability are among the physicochemical characteristics of the drug that can be fine-tuned using this method. Solution crystallization, solid-state grinding, and solvent evaporation are among techniques that can be used to accomplish co-crystallization; each has unique benefits with regard to efficiency and scalability. Because of this, co-crystallization is a particularly useful and often used method for improving solubility in medication development.

Keywords: Solubility, Co-crystallizations, BCS, API, Co-former, Dissolution.