Abstract

FORMULATION AND DEVELOPMENT OF ANTI-TUSSIVE SYRUP

*Sushant Shinde, Shubham Prabhu, Prachi Telavane and Mohit Jadhav

Abstract

This study focuses on the development of a natural polyherbal cough syrup using extracts of Madhuca longifolia (Mahua), Adhatoda vasica (Adulsa), Syzygium aromaticum (Clove), Cinnamomum zeylanicum (Cinnamon), and honey each chosen for their established respiratory benefits. Mahua acts as the primary active pharmaceutical ingredient (API), contributing significant expectorant and soothing effects that aid in the clearance of bronchial secretions. The herbal extracts collectively exhibit synergistic antitussive, mucolytic, antiinflammatory, and antimicrobial properties. Adhatoda vasica provides bronchodilatory and mucolytic actions through vasicine; Syzygium aromaticum offers analgesic and antimicrobial benefits via eugenol; Cinnamomum zeylanicum adds antitussive and antioxidant activity due to cinnamaldehyde; and honey acts as a natural demulcent, improving palatability and soothing the throat. The final syrup formulation underwent evaluation for organoleptic characteristics, physicochemical parameters, and microbial quality. Preliminary results indicate that the syrup is stable, palatable, and exhibits mild antimicrobial activity, suggesting potential effectiveness in managing both dry and productive cough. Further pharmacological validation and clinical studies are recommended to support its therapeutic use.

Keywords: Madhuca longifolia, Anti-Tussive, Cough, Mucus, Evaluation, Soxhelet.