Abstract

NANO-CARRIERS-BASED APPROACHES FOR TOPICAL WOUND THERAPY AND CARE

Meghna Singh* 

.

Abstract

Background: Wound management is challenging task for researchers and also a burden on health care system. The topical infections have problems like moist condition, microbial contamination, environmental factors, forming debris etc. These conditions caught up wound into acute and chronic situations that are miserable for patients. The conventional techniques were applied but it has some limitations such as less moisture absorbent capacity, lower bioavailability and patient compliance. The modern techniques may overcome the problems of wound infections. Main body: The wound healing is a complex process. Basically, it has four phase, haemostasis, inflammation, proliferative phase and remodelling. Particularly, natural and synthetic sources were developed for the management of wound. There were various natural sources such as curcumin, Aloe vera, pomegranate, Calendula officinalis, alginate etc. used in the healing of wound infections. Moreover, nano-medicines plays a vital role in wound healing management. The nano-based introduced nanoparticles, polymeric nanoparticle, liposomes, niosomes, silver nanoparticles, gold nanoparticels etc, for effective healing of wound infections. In the coming years it will be anticipated that the market value of wound healing products will upraise. The regulatory bodies designed their protocol according to the patient compliance values. Conclusion: Overall, the management of wound is difficult. The researchers find advanced techniques for faster wound healing. The nanotechnology establish better results like faster wound healing, high bioavailability rate, low toxicity and effective therapeutic rate for management of infectious wound.

Keywords: Nanomedicine, wound healing, nanoparticles, wound remodeling, micelles.