Abstract

FORMULATION AND EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF LEVETIRACETAM

V. Mamatha*, Dr. Avinash Dundigalla and Dr. A. Yasodha

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Abstract

For extended release drug delivery systems, the oral route of drug administration has, by far received more attention as it is natural uncomplicated, convenient and safer route. Matrix tablets composed of drug and release retarding material (e.g. polymer) offer the simplest approach in designing the extended release system. Long-term adherence to anti-epilepsy drug (AED) regimens is frequently suboptimal. Poor adherence to therapy is associated with a number of negative consequences, including an increase in patient seizures and mortality. The present study was aimed to study the effect of Chitosan and Sodium Alginate on the release rate Levetiracetam for the preparation of extended release formulations. Matrix Tablets were prepared by wet granulation method and subjected for Physiochemical and in-vitro evaluation tests. The results were shown that the prepared were found to be within the pharmacopeial limit and with good release characteristics.

Keywords: Levetiracetam, Chitosan, Sodium Alginate, Extended release, Matrix Tablets.