Abstract

A COMPREHENSIVE REVIEW: LIQUISOLID TECHNIQUE

Vaibhav N. Patil*, Yashpal M. More and Ashish M. Sonawane

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Abstract

Most newly developed drug choices are lipophilic and have poor water solubility. One of the biggest challenges facing the pharmaceutical business is improving these medications' solubility and bioavailability. A new and improved method to address the problem is the liquidsolid technique, It involves transforming the medication from a liquid into a powder that seems dry, non-adherent, free-flowing, and compressible. The purpose of this study is to provide an overview of the liquisolid technique and to summarize the evolution of its pharmaceutics applications. This strategy's main advantages are its low cost, processing simplicity, and vast industrial manufacturing potential. This technique is a relatively new technology to both speed up the dissolution of poorly water-soluble medications and effectively delay their release. In order to improve drug photostability in solid dosage forms, the liquisolid method has also been investigated as a way to lessen the effect of pH variations on drug release and as a workable alternative to conventional coating. Overall, the liquisolid method is a newly developed and promising tool for enhancing drug dissolving and sustaining drug release, albeit its prospective applications in pharmaceutics are still being explored.

Keywords: Liquisolid Technique, Microparticles, PB screening design, Drug enhancement.