Abstract

“DESIGN, DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCH CONTAINING ONDANSETRON HYDROCHLORIDE AND DILTIAZEM HYDROCHLORIDE”

Assistant.Prof.Kokate Sudhir Govind.*, Prof. Tarkase Kailas, Jogdand Trimbak, Dr.Dushant Gaikwad.

Abstract

The purpose of this research was to develop a matrix-type Transdermal therapeutic system containing drug Ondansetron hydrochloride (OSH) with using different ratio of HPMC K4M, and EC, ERLPO in combination by mercury substrate method. The polymers were weighed in requisite ratio and dissolved in Methanol. Polyethelene glycol 40% w/w total weight of polymer composition was used as plasticizer. Methanol was added 5 ml of the total weight of polymers; homogeneous dispersion was formed by slow stirring with a mechanical stirrer.F4 showing sustain release up to 24 hr with 87.21% and 93.56% drug permeation shows sustain release of Ondansetron hydrochloride and Diltiazem hydrochloride Drugs through cadaver skin,100% flatness, 51no.of fold of folding endurance test which showing good flexibility and less brittleness, moisture content was 0.851± 0.67 % and moisture uptake was 3.198± 1.87%, good tensile strength i.e. 58.1×104± 0.87dynes/cm2, so according to all parameter the F4 was the optimized formulation.

Keywords: Ondansetron hydrochloride, Hydrophilic and hydrophobic polymers, Sustained release, Transdermal patches.