Abstract

FORMULATION AND EVALUATION OF ITRACONAZOLE LOADED NANOSPONGES

*Gaurav Nawale, Yash Pawar, Siddhi Chaure, Vaishnavi Gugale, Rahul Lokhande, Akshay Fulsundar

Abstract

Nanosponges are a novel class of hyper cross-linked polymer-based colloidal structures made of sub-microscopic particles with cavities a few nanometers wide.[1,6,11] This study aimed to formulate and evaluate itraconazole-loaded nanosponges and systemic fungal infections.[2] Nanosponges were prepared using the emulsion solvent diffusion method, incorporating different ratios of polymer and crosslinker.[ 1,5,12] Particle size, entrapment efficiency, drug loading, and in vitro drug release were all evaluated for the resultant nanosponges. Nanosponges are effective drug carriers for compounds with low solubility and high permeability.[11] Hydrogels, being threedimensional porous structures, are commonly used in drug delivery systems. Recent advances have resolved many pharmacological limitations of hydrogels by synthesizing them using hydrophobic polymers cross-linked with water-soluble polymers.[7,25] Nanosponges, often synthesized from carbon-containing polymers, are porous (1–2 nm pores) and can absorb and release small molecules in a controlled manner.[10,17] These findings suggest that itraconazole-loaded nanosponges are a promising approach for enhancing the delivery and therapeutic efficacy of itraconazole.[12,21]

Keywords: Nanosponges, Hydrogel, Antifungal activity, Drug deilivery system.