Abstract

A NOVEL ANTICOAGULANT THERAPY REVIEW

Priyanshi Jain*, Riya Mondal, Aditya Pant and Dr. B. S. Sonigara

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Abstract

Novel oral anticoagulants (NOACs) also termed as, direct oral anticoagulants (DOACs) have revolutionised the management of thromboembolic disorders, offering improved efficacy and safety profiles over traditional agents such as warfarin, including narrow therapeutic window, drug-food interaction, and need for routine monitoring. This review provides an overview of the current state of novel anticoagulants, mainly focusing on DOACs targeting factor Xa and thrombin, which includes direct thrombin inhibitors and factor Xa inhibitor. We discuss the pharmacological properties, clinical efficacy and the safety for various clinical conditions like venous thromboembolism, atrial fibrillation and stroke. We also discuss developments in reversal agents by examining current evidence and the challenges. Finally, we highlight the ongoing research and future in development of novel anticoagulants.

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