Abstract

COMPARATIVE STUDY ON THE SOLUBILITY ENHANCEMENT OF POORLY WATER-SOLUBLE DRUGS USING SOLID DISPERSION TECHNIQUES

Chaitali Raut*, Shreyash Gosatwar, Sejal Khadse, Mrs. Rupali Chavhan

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Abstract

The solubility of a drug significantly influences its bioavailability, therapeutic efficacy, and overall success as a pharmaceutical agent. Approximately 40% of new chemical entities (NCEs) identified through drug discovery programs exhibit poor water solubility, posing substantial challenges in drug development and delivery (Kalepu & Nekkanti, 2015). Poorly water-soluble drugs often demonstrate low dissolution rates in the gastrointestinal tract, leading to inadequate absorption and suboptimal therapeutic outcomes (Savjani et al., 2012). To address these challenges, various formulation strategies have been developed to enhance the solubility and dissolution rates of hydrophobic drugs. Among these, solid dispersion techniques have emerged as a promising approach. Solid dispersions involve dispersing poorly soluble drugs within a hydrophilic carrier matrix, resulting in improved wettability, reduced particle size, and, in some cases, transformation of the drug into an amorphous state, thereby enhancing solubility and dissolution rates (Vasconcelos et al., 2007).

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