Abstract

“A PROSPECTIVE STUDY ON THE RATIONAL USE OF RESTRICTED ANTIBIOTICS IN A TERTIARY CARE TEACHING HOSPITAL”

Dr. Vinuth Chikkamath*, Prof. J. S.Venkatesh, Dona Sajan, Feba G. Jose, Ferina U., Nashreennisa Begum

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Abstract

Background: The prospective study of restricted antibiotics promotes the appropriate use of restricted antibiotics by selecting appropriate dose, duration, frequency and route of drug administration. The appropriate use of restricted antibiotics has the potential to improve the safety and efficacy of the drug. Objective: To assess the prescribing pattern of restricted antibiotics among inpatients of different wards. To assess the appropriateness of restricted antibiotics use with diagnosis and bacteriological findings. To assess the outcome of restricted antibiotics utilization pattern. Methodology: A prospective study was carried out among the inpatients in general medicine, ortho and ICU departments in a tertiary care teaching hospital. Results: Within the sample size, most of the restricted antibiotics were prescribed among 41-60 year age group (39.1%) followed by 61-80 year (37.33%). Among the prescribed restricted antibiotics, the most commonly prescribed drug was Piperacillin /Tazobactam(38.00%) followed by Linezolid(22.48%), Amikacin(16.10%), Meropenem (10.06%), Cefixime (6.04%), Ciprofloxacin (4.69%), Vancomycin (2.01%) and Gentamycin (0.67%). Out of 225 sample size, 169 were found to be monotherapy and 56 were combination therapy. Among the total sample size 199 showed DI, 35 were major, 91 were moderate and 73 were minor in severity. On analyzing the number of restricted antibiotics per treatment chart, 146 showed DI. Among 146, the most common DI caused by Amikacin (43.83%) followed by Piperacillin/Tazobactam (23.28%), Linezolid (16.43%), Ciprofloxacin (10.27%), Vancomycin (2.05%), Meropenem (0.68%), Cefixime (0.68%). Out of 225 sample size, 298 were restricted antibiotics and 331 were antibiotics. From our study, out of 225 cases, 171 were without culture sensitivity test and 54 with test. Out of 225 cases, 179 were rational and 46 were irrational. Conclusion: The WHO has recognized antibiotic resistance as one of the most significant threat to public health. These antibiotics are specialized drugs designatedfor use in specific condition and is essential to combat antibiotic resistance and ensure effective treatment of infections. The most commonly prescribed restricted antibiotics from our hospital is Piperacillin/Tazobactam followed by Linezolid, Amikacin, Meropenem, Cefixime, Ciprofloxacin, Vancomycin and Gentamycin. Most of the prescriptions were observed to be rational.

Keywords: Restricted antibiotics; Prospective study; Rational use of antibiotics; Irrational use of antibiotics.