Abstract

CURRENT REVEIW ON ORAL THIN FLIM- ALTERNATE FOR CONVENTIONAL DOSAGE FORM

*M. Arunprasath and M. Mohamed Nasurudeen

Abstract

In the field of pharmaceutical formulations, oral thin films, or OTFs, have piqued the interest of scientists and researchers in recent years and are being considered as a cutting-edge method of creating effective drug delivery systems. At the moment, OTFs are being considered as a potential substitute for the traditional solid and liquid oral dose forms. Drugs are administered by oral thin films, which are dissolving films or oral drug strips that adsorb in the mouth and guarantee that the drug enters the bloodstream immediately. Thin films give the medication the ability to avoid first-pass metabolism, act quickly, are more practical for elderly and pediatric patients who frequently experience nausea or difficulty swallowing, are simple to package and transport, and offer numerous other benefits over conventional dosage forms. However, only a small number of medications have seen commercialization of these OTFs, primarily in the US, Japan, and EU markets. Numerous studies are being conducted to enable the formulation of various medication types into these strips and to address some of the issues encountered during production, scale-up, and the cost-effectiveness of the OTFs. The main focus of the review is on the various manufacturing techniques used to create OTFs, such as solvent extraction, hot melt extrusion, solid dispersion extrusion, and semi-solid casting, as well as cutting-edge techniques like flexographic printing technologies, and the financial and technical challenges that producers face when producing them on a large scale. Additionally, it outlines the present and projected global and Indian OTF market trends and evaluates the viability of this novel strategy in light of the available information and technology resources.

Keywords: Oral thin flim, first -pass metabolism, conventional dosage forms.