Abstract

REVOLUTIONIZING DIABETES CARE: INSIGHTS INTO NEW THERAPEUTIC APPROACHES AND TECHNOLOGIES –A REVIEW

Podili Niranjan Rao*, Gangavaram Jyothi Reddy, Obulam Vijaya Sarathi Reddy, Podili Chandrakala, Budimepalli Swetha and Vuluchi Srinivasa Rao

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Abstract

Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, continues to pose a major global health challenge. Conventional therapies, though effective in glycemic control, often fall short in preventing long-term complications and ensuring patient compliance. The emergence of next-generation therapeutics offers promising alternatives for more effective, individualized, and sustainable diabetes management. This review explores cutting-edge therapeutic strategies, including incretin-based therapies, SGLT2 inhibitors, dual and triple agonists, gene therapy, stem cell-based approaches, nanotechnology-enabled drug delivery systems, and artificial pancreas technologies. We also delve into digital health innovations such as continuous glucose monitoring (CGM), closedloop insulin delivery systems, and mobile health applications powered by artificial intelligence (AI). These advanced modalities not only aim to restore metabolic homeostasis but also address the broader aspects of diabetes care, including patient empowerment, reduced treatment burden, and enhanced quality of life. Despite their potential, these therapies face significant translational challenges including regulatory hurdles, cost-effectiveness, and long-term safety concerns. This review provides a comprehensive overview of the current landscape and future directions in the evolution of diabetes therapeutics, highlighting the need for integrated, multidisciplinary approaches for optimal disease control. Treatment:

Keywords: Diabetes mellitus, novel therapeutics, gene therapy, incretin, SGLT2 inhibitors, artificial pancreas, stem cell therapy, nanotechnology, digital health.