Abstract

PHYSIOCHEMICAL EVALUATION OF PSIDIUMGUAJAVA LEAVES EXTRACT LOADED BUCCAL PATCH FOR ENHANCED MUCOSAL ABSORPTION

*V. Ashlin Viji, Dr. J. Jaslin Edward, T. Jaghatha, Ahliesh S., John Jaishin D., Suguna D., Vibishya Varghese and Ebenazer Naveen Y.

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Abstract

Psidium guajava L. (guava), a member of the Myrtaceae family, is a widely cultivated tropical and subtropical plant known for its nutritional fruits and medicinal properties. Guava leaves, traditionally used in various folk remedies, are a rich source of bioactive phytochemicals, including flavonoids (such as quercetin), tannins, saponins, carotenoids, and essential oils. These compounds are associated with a wide range of pharmacological effects. In addition to antimicrobial and antioxidant activity, the extract showed promising anti-inflammatory and antidiabetic potential in vitro, likely due to its ability to inhibit key enzymes such as alpha-amylase and lipoxygenase. Cytotoxicity assays confirmed its safety at therapeutic doses, supporting its use in traditional medicine for treating conditions such as diarrhea, wounds, diabetes, and infections. Five patches of Psidiumguajava buccal patches were prepare by solvent casting technique. From the optimization, best two formulations psidiumguajava (drug), Polymer (hpmc), water, Propyel glycol, Glycerine were selected based on folding endurance and optimal tensile strength. Among these, the formulation showed maximum % Moisture uptake (3.57),% Moisture content (3.27), Thickness (0.35mm), Folding endurance (265),%Drug content (96.24), Percent Elongation (97), Tensile strength (7.66 Kg mm2), Adhesive strength (21.66). Stability study was performed for period of three months. The physiochemical parameters like visual appearance, color, texture and drug content and drug release were studied. The results showed that there is no significant change from its initial nature till the period of three months at 40°C ±2°C/75±5% RH.

Keywords: Paidium guava, Anti-inflammatory, amtidiabetic, buccal patch, hysiochemical parameters.