Abstract

EXTENDED RELEASE PELLETS: NOVEL APPROACH TO TARGETED DRUG DELIVERY SYSTEM

*Jayashri J. Dandale, Vinayak Rasal, Dhananjay Giram, Pratiksha Rajguru, Jagdish Jadhav, Kiran Ukey and Deep Chaudhari

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Abstract

A variety of real and perceived benefits for patients, extended release pharmaceuticals have recently emerged as a highly helpful tool in medical practice. Due to its convenience, Among all drug delivery methods oral administration is a particularly often used method for various pharmacological compounds, which improves patient compliance. For medications that are taken orally yet have a short halflife and a high frequency of dosage, an oral extended-release drug delivery system represents a very promising strategy. By keeping the prescribed dose of the medicine from fluctuating in the body, extended release also offers a viable means of reducing pharmacological adverse effects. Drug delivery systems that use oral extended release drugs will keep up to dominate the market. The prolonged release solution will improve patient comfort and compliance while optimizing a drug's therapeutic impact and safety. Multiparticulate drug delivery methods are particularly wellsuited for producing oral formulations with extended release that have a minimal chance of dosing off, may be blended to achieve various release patterns, and have a short and repeatable stomach residence time, according to recent developments. Several elements including the amount of medicine in the pellets and the carrier used to produce them, affect how much medication is discharged from them. In light of this, pellets provide a wealth of potential for creating novel controlled and prolonged-release oral formulations.

Keywords: Extended pellets, Extrusion Spheronization Process, Lyophilization method.