Abstract

MOLECULAR DOCKING STUDIES OF PHYTOCONSTITUENTS FROM BLEPHARIS MADERASPATENSIS AGAINST TARGET PROTEINS INVOLVED IN DISEASE PATHWAYS

Suresh V*, Senthilkumar S.K, Jayaseelan K, Johnson Mary A, Punitha Sri R.

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Abstract

Diabetes mellitus (DM) occurs when the body experiences insulin deficiency or is unable to use insulin appropriately, which increases the blood glucose levels over the threshold. Blepharis maderaspatensis leaf is a widely used and scientifically proven herbal medicine to treat DM. The demand for the development of new drugs has prompted in silico studies of antidiabetic insulin-resistant activity. This study aims to conduct a comprehensive study of the types of flavonoid and nonflavonoid compounds that have antidiabetic activity in insulin resistance mellitus using in silico approaches. The literature review was conducted in accordance with the offered reporting items for systematic review. Major bibliographic databases, i.e. Scopus, PubMed, and DOAJ, covering original articles about the aforementioned issues between January 1, 2011 and April 30, 2025 were used. The results exhibit that flavonoids, including quercitrin, tropane, quercetin, Indole, 9-eicosyne, caffeic acid, kaempferol, Myricitin, L-Rhamnose, Camphor, Purine, cholestan-3-ol, Diethyl phthalate, palmitic acid, Squalene, Phytol, Rutin, Isoquinoline, Ursane, Lupane, Ferulic acid, Oleanane, Quercitol, Gallic acid, Cyanidin-3,5-diglucoside. have potential insulin-resistant antidiabetic activity in silico. This has broadened the research into the development of new drugs.

Keywords: Antidiabetic, Phytoconstituents, insulin resistant, blepharis maderaspatensis, Molecular docking.