Abstract

CASE REPORT: STEVENS-JOHNSON SYNDROME INDUCED BY OFLOXACIN, KETOROLAC, AND ACECLOFENAC IN A PLHIV PATIENT WITH HYPOTHYROIDISM

Dr. Subhashini M., Ragul Ezhumalai*, Pavithran G., Ragu Ram C. R., Kavya P., Priya Dharshini G.

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Abstract

Stevens-Johnson Syndrome (SJS) is a rare, life-threatening mucocutaneous reaction characterized by extensive necrosis and detachment of the epidermis. It is most commonly triggered by adverse drug reactions, particularly in immunocompromised patients. This report details the case of a 43-year-old male with newly diagnosed HIV and hypothyroidism who developed SJS following the administration of ofloxacin, ketorolac, and aceclofenac. The patient presented with persistent oral ulcers and widespread fluid-filled lesions. Prompt recognition, systemic corticosteroid therapy, supportive care, and multidisciplinary management resulted in complete clinical resolution. This case emphasizes the importance of pharmacovigilance and proactive management strategies, especially in immunocompromised individuals.

Keywords: Stevens-Johnson Syndrome, HIV, drug-induced, ofloxacin, ketorolac, aceclofenac, hypersensitivity, adverse drug reaction.