Abstract

FAST DISINTEGRATING IBUPROFEN TABLETS: A PATIENTFRIENDLY APPROACH FOR RHEUMATOID ARTHRITIS TREATMENT

Varsha Rane*, Tukaram Madhav, Vaibhav Dalvi, Shashank Naikawadi and Rohit Naik

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Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by persistent joint inflammation, causing pain, stiffness, and a decline in quality of life. Although ibuprofen is commonly used to manage these symptoms, traditional oral tablets can be difficult to swallow especially for elderly patients or those with swallowing difficulties. This study focused on developing fast-disintegrating tablets (FDTs) of ibuprofen to improve ease of administration and speed up symptom relief. Formulations were prepared using the direct compression method and included super disintegrants like sodium starch glycolate, croscarmellose sodium, and Crospovidone. Among the tested formulations, the optimized batch (F4) showed good flow properties before compression, consistent quality after compression, a rapid disintegration time of just 25 seconds, and a drug release of 62.55% within 30 minutes during in vitro testing. These findings suggest that ibuprofen FDTs could serve as an effective and patient-friendly alternative to conventional tablets, offering faster relief and greater convenience for individuals with RA.

Keywords: Rheumatoid arthritis, Fast-disintegrating tablets, Ibuprofen, Direct compression, COX enzymes.