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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOLOGICAL ACTIVITY OF SOME NOVEL BENZIMIDAZOLE DERIVATIVES

*Maruthamuthu, Bharathi Dileepan, Shameela Rajam, B.R. Venkatraman, Christina Ruby Stella, Ranjith

Abstract

The reaction of benzoic acid derivatives with ammonium thiocyanate yield 4-thiocyanatobenzoicacid. The thiocyano-benzoicacid was condensed with o-phenylenediamine and carbon disulphide to get benzimidazole. These compounds were synthesized in good yield and their structures were confirmed by IR, 1H-NMR and 13C-NMR. Antimicrobial activity against bacteria and fungi, anti-inflammatory activity and analgesic activity were studied for the synthesized compounds.

Keywords: Benzimidazole, thiocyanate, o-phenylenediamine, pharmacological activity.

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