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Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF FAST DISINTEREATING COMBINATION AMLODIPIN BESYLATE AND ATENOLOL TABLET USING NATURAL DISINTIGRANT

Yadav Nilesh M*, Kumar Rachana S, Dr. Kshirsagar Sanjay J.

Abstract

The present study aimed to develop fast disintegrating tablets ofAmlodipine besylate and Atenolol using natural disintegrants like Guargum, Gum Karaya & synthetic super disintegrants likeCroscaramellose sodium, Sodium starch glycolate and crospovidone.Disintigrant concentration was taken in this studies 1%, 2%, 3%.Precompressional studies revealed good micromeritic properties ofpowder blend. Various Formulations of were prepared by directcompression method and were evaluated for their physico chemicalproperties, drug release and stability studies The hardness, friability,drug content and disintegration time of fast dissolving tablets werefound uniform and reproducible. Dissolution test shows that 3 % w/wconcentration was found optimum for both disintigrant. Optimizedformulation was compare with marketed formulation. Drug release ofmarketed formulation was only 97.65% AML 98.91% ATEN at the end of 24 min which ismuch less as compared to the optimized batch (F3 & F6) which showed drug release of101.75% AML 100.52% ATE for F3 batch and 99.92% AML 100.51% ATEN for F6 batch atthe end of 18 min.

Keywords: Guar gum, Gum karaya, natural disintegrant, Fast disintegrant tablet.


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