Abstract

DEVELOPMENT AND CHARACTERIZATION OF EYE DROP CONTAINING MOXIFLOXACIN HYDROCHLORIDE FOR BETTER THERAPEUTIC EFFECT

Harsha K. M.*, Gururaj S. Kulkarni*, Padmaa M. Paarakh, A. Muthu Kumar

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Abstract

This study aimed to develop and assess eye drops containing 4th generation fluoroquinolone antibiotic as viable therapy for ocular infection. A wide range of bacterial eye infections can be treated with fluoroquinolones, a class of broad-spectrum antibiotics effective against both gram-positive and gramnegative bacteria. To improve medication stability and ocular tolerability, the formulation procedure involved choosing suitable excipients, regulating the pH, and guaranteeing isotonicity. Comprehensive physicochemical assessments, including viscosity, pH, and sterility tests, were performed on the created eye drops. Ex-vivo cornea permeation studies were used to identify the pharmaceutical release profile using simulated tear fluid, and common eye pathogens were used to assess the antibacterial activity. The results indicate that because the produced fluoroquinolone eye drops have strong antibacterial action, steady drug release, and stability, they may be used clinically to treat ocular infections. To assess the safety and therapeutic efficacy in vivo, more research is advised.

Keywords: Fluoroquinolones, Eye drops, Ocular infections, Antibacterial activity, Controlled drug release.