Abstract

TRANSDERMAL PATCHES FOR SUSTAINED RELEASE OF ANTI-INFLAMMATORY DRUGS

Rajan Chaudhary* and Dr. N. Trilochana

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Abstract

Transdermal drug delivery systems (TDDS) offer a promising alternative for the sustained release of anti-inflammatory drugs, enhancing therapeutic efficacy while minimizing systemic side effects. This study focuses on the formulation, development, and evaluation of transdermal patches designed for the controlled release of selected non-steroidal anti-inflammatory drugs (NSAIDs). The rationale behind utilizing transdermal patches lies in their ability to bypass first-pass metabolism, maintain consistent plasma drug concentrations, and improve patient compliance. Various polymers such as hydroxypropyl methylcellulose (HPMC), ethyl cellulose (EC), and polyvinyl alcohol (PVA) were employed as matrix formers, while permeation enhancers were incorporated to facilitate drug transport across the skin barrier. The patches were subjected to physicochemical characterization, in vitro drug release studies, and skin permeation tests to assess their performance. Results indicated a sustained release profile over 24 hours, with optimal mechanical properties and bio adhesive strength. These findings support the potential of transdermal patches as an effective platform for the prolonged delivery of anti-inflammatory agents in the management of chronic inflammatory conditions.

Keywords: Transdermal drug delivery systems, Anti-inflammatory drugs, Non-Steroidal Anti-Inflammatory Drugs.