Abstract

CHARACTERIZING THE INHERENT PROPERTIES OF PLURONIC F-127 IN CARBAMAZEPINE SUPPOSITORIES

Lerissa Princy Mascarenhas* and Renita Jyothi Monis

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Abstract

The main goal of rectal administration, as opposed to oral administration, is to provide an effective method of delivering medication to pediatric and geriatric patients. There is a significant need for new non-oral formulations for antiepileptic drugs when oral administration is not possible when the person is unconscious or has swallowing difficulties. The present study aims to formulate Carbamazepine suppositories with Pluronic F127 base by fusion method. Pluronic F127 is an amphiphilic polymer that possesses unique thermo-responsive properties. Prepared suppositories were evaluated for general appearance, weight variation, drug content, and dissolution. Drug release was found in the range of 38.46% -56.93%, for F1- F5 respectively. Drug release was subjected to different kinetic models from the formulation, out of those models it was found that drug release followed the Higuchi model. The present study shows F1 (50:50) as a better formulation among the other four in terms of appearance, content between 61.36% and 97.44%, weight variation, and drug release showing purely by dissolution-controlled release.

Keywords: Carbamazepine, Antiepileptic drug, Pluronic F127, suppositories.