Abstract

FORMULATION AND IN VITRO EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF LOSARTAN POTASSIUM USING SYNTHETIC AND NATURAL POLYMERS

Raut D.B., Sakhare R.S. *, Kankudte A.D., Muli P.N, Bharkad V.B.

Abstract

The objective of this study was to develop mucoadhesive buccal tablets of Losartan Porassium using both Synthetic and Natural mucoadhesive polymers and evaluate results of both polymers. Losartan Potassium is Angiotensin receptor blocker having short biological half-life (2hr), high first-pass metabolism and poor oral bioavailability (33%), hence an ideal candidate for buccal delivery system. The buccal tablets of 150 mg were prepared by using synthetic (Carbopol 934p as primary and HPMC K15M and SCMC as secondary polymer) and natural polymers (Sodium Alginate as primary and Guar Gum and Xanthan Gum as secondary polymers) separately in various concentrations by direct compression method, eight batches were prepared. Estimation of Losartan potassium was carried out spectrophotometrically at 205 nm. FTIR spectroscopy method revealed that there was no interaction between Losartan potassium and polymers. The tablets were evaluated for hardness, thickness, weight variation, friability, drug content, surface pH, swelling index, in vitro drug release, mucoadhesive strength and in vitro Residence time. Among synthetic polymers FS2 and among natural polymers FX2 batches showed better results. Data of in-vitro release from tablets were fed into kinetic models (Zero order, first order, Higuchi and Korsmeyer-Peppas models) to explain release profiles. The optimized formulations showed zero order release.

Keywords: