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Abstract

REVIEW ON: LYOPHILIZATION PROCESS OF PHARMACEUTICALS

Siddhi Pandhare*, Mallinath Harwalkar, N.B Mahale, S.R. Chaudhari

Abstract

Lyophilization (Freeze drying) often used to prepare dry pharmaceutical formulation to achieve commercial viable shelf life. Properly freezed dried product do not need to refrigerarate it can be stored at room temperature also. Lyophilization is common but cost intensive. Suitable parameters of process application allow us to obtain best quality products compared to products dried with traditional methods. In pharmaceutical field lyophilization has become important subject to ongoing development and its expansion. Process consists of three steps: Freezing, primary drying, secondary drying. Article focused on how different factors affect lyophilization process and also gives a comprehensive list of excipients used in lyophilized formulations.

Keywords: KEYWORDS: Lyophilization, Freezing, primary drying, secondary drying.


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