Abstract

LITERARY, ANALYTICAL AND OBSERVATIONAL CLINICAL EVALUATION OF 500 MG DM CAPSULE, IN DIABETES MELLITUS (MADHUMEHA)

Dr. Ravi Raj M. D. Ayurveda and Dr. Pramod Bhardwaj M. D. Ayuvreda

Abstract

Diabetes Mellitus has been recognized as a significant health disorder since ancient times, affecting populations across various civilizations. Diabetes Mellitus is a complex metabolic disorder characterized by persistent hyperglycemia resulting from deficient insulin secretion, insulin resistance, or both. Its global prevalence has risen sharply in recent decades, primarily due to sedentary lifestyles and unhealthy dietary habits. In Ayurvedic literature, this condition closely corresponds to Madhumeha, a subtype of Prameha, which arises from the vitiation of Kapha dosha, dysfunction of Medo dhatu, and impairment of Agni. These pathophysiological changes disrupt normal metabolic processes, leading to the manifestation and progression of the disease. Understanding Madhumeha through the lens of Ayurveda offers a holistic framework for its prevention and management. According to the latest data from the International Diabetes Federation (IDF), approximately 72.9 million individuals in India are currently living with Diabetes Mellitus. In classical Ayurvedic texts, this condition is described as Madhumeha, a subtype of Vataja Prameha, characterized by the excessive elimination of sweet-tasting urine. Madhumeha is considered a chronic metabolic disorder arising from dosha imbalance—particularly Vata—along with Medo dhatu dysfunction and impaired Agni, aligning closely with the clinical features of type 2 Diabetes Mellitus. The present study was conducted on 130 patients presenting with chief complaints such as generalized body ache, sweet taste in the mouth, burning sensation in the soles, excessive hunger (Ati-bubhuksha), excessive thirst (Ati-trishna), increased psychological stress, and frequent micturition (Prabhuta-mutrata). Based on clinical evaluation, physical findings, and relevant biochemical investigations, the condition was diagnosed as Madhumeha (Type 2 Diabetes Mellitus), a chronic metabolic disorder described in Ayurveda under the broader classification of Prameha. The treatment protocol included the administration of 500 mg of DM Capsule twice daily, in conjunction with prescribed dietary modifications and lifestyle interventions. Patients were monitored through regular follow-up visits at seven-day intervals over a period of two months (60 days). Notable clinical improvements were observed after the first month of treatment, indicating a significant therapeutic response. The therapeutic intervention comprised the administration of 500 mg DM Capsule twice daily, alongside individualized dietary regulation and lifestyle modification. Patients were assessed at regular intervals of seven days over a total duration of 60 days. Significant clinical improvement was observed by the end of the first month, suggesting a positive therapeutic response to the integrative management approach. The study administered a total daily dose of 1 gram of DM Capsule powder (500 mg taken twice daily on an empty stomach, before breakfast and dinner) over a period of 60 consecutive days. The treatment resulted in a statistically significant improvement in glycemic control among diabetic patients (P

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