Abstract

PHARMACOTHERAPEUTIC MANAGEMENT OF INFANTILE EPILEPTIC SPASM SYNDROME (IESS): A CASE STUDY

Dr. Jasmy E. S.*, Mahitha, Dr. Vismaya V. R., Shinju Somaraj, Dr. Nithin Manohar R., Dr. Prasobh G. R.

Abstract

Infants with Infantile Epileptic Spasm Syndrome, formerly known as West syndrome, suffer from a severe form of epileptic encephalopathy. It is distinguished by Clusters of tonic spasms of the axial and limb muscles, known as epileptic spasms and hypsarrhythmia which is a disordered and chaotic brain wave pattern. Psychomotor delay or arrest may also occur, which can result in long-term disabilities. Numerous factors, such as genetic mutations, brain disorders, and the presence of other medical conditions, can lead to IESS. About 10–40% of patients have cases where no underlying cause can be found. Adrenocorticotropic hormone, vigabatrin, and high dosages of oral steroids are the most effective treatments. Age of onset is usually between 4-6 months, with the majority of cases presenting within the first year of life.

Keywords: West Syndrome, Hypsarrhythmia, Psychomotor delay, Mutation, Adrenocorticotropic hormone.