Abstract

TRANSETHOSOMES FOR SYSTEMIC LUPUS ERYTHEMATOSUS: A PROMISING APPROACH IN TARGETED DRUG DELIVERY

Naga Chandrika P, Latha Vaka, Shekar Ashaboina, Dharmavaram Jukigiri Vineela,

Abstract

Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder characterized by widespread inflammation and tissue damage. The management of SLE is challenging due to its heterogeneous nature and the limitations of current therapeutic options. Traditional drug delivery systems often face issues such as poor bioavailability and undesirable side effects, highlighting the need for innovative approaches. Transethosomes, lipid-based carriers, offer improved drug permeability through the skin, making them promising for the transdermal delivery of therapeutic agents. The incorporation of ethanol and surfactants into transethosomes enhances their stability and drug-loading capacity, thereby increasing therapeutic efficacy. This review aims to explore the formulation of transethosomes and their potential advantages in the treatment of SLE, emphasizing the need for further research in this field. The article underscores the importance of targeted drug delivery systems in improving patient compliance and therapeutic outcomes, particularly in chronic conditions like systemic lupus erythematosus that require long-term management.

Keywords: Transdermal Drug Delivery System, Liposomes, Niosomes, Transferosomes, Ethosome, Transethosomes, Systemic lupus erythematosus.