Abstract

MICROARRAY PATCH TECHNOLOGY: A NEW FRONTIER IN DRUG DELIVERY

Prema R.^*, Meenakshi M., Prabhakaran M. and Dr. Sankar C.

Abstract

Transdermal drug delivery provides a different approach to oral and injectable methods, effectively overcoming challenges like low bioavailability and patient discomfort. However, passive skin permeation remains a challenge, particularly for poorly soluble drugs. Microarray patches (MAPs) have emerged as an advanced transdermal delivery system that enhances drug absorption using micron-scale needles, significantly improving therapeutic efficacy compared to conventional patches. MAPs provide a minimally invasive, self-administered alternative, reducing the burden on healthcare personnel while eliminating sharps waste and minimizing needle-stick injury risks. Their versatility extends to various drug delivery applications, including vaccines, insulin, contraceptives, and cosmetic treatments. Different microneedle types solid, dissolving, hydrogel-based, coated, and hollow are designed to optimize drug delivery based on specific therapeutic needs. Despite their growing commercial interest, challenges remain in optimizing fabrication, characterization, and large- scale production for widespread clinical adoption. This review explores the current advancements in microneedle technology, detailing fabrication techniques, evaluation methods, and clinical applications, particularly in contraceptive and antiretroviral drug delivery. By highlighting the main challenges and potential opportunities, this review seeks to lay the groundwork for future research and encourage the wider integration of MAPs in clinical practice.

Keywords: Microneedle patch, Drug delivery, Fabrication techniques, 3D Printing technology, Characterization, Patent search.