Abstract

MAHA-PANCHAGAVYA GHRITA IN THE MANAGEMENT OF APASMARA: AN EVIDENCE-BASED REVIEW

Dr. Anjali Punia* and Dr. Rakesh Pawar

Abstract

Background: Apasmara (Epilepsy) is described in Ayurvedic texts as a chronic neurological disorder characterized by sudden episodes of transient loss of consciousness associated with involuntary movements and abnormal behavior. Maha-Panchagavya Ghrita, a classical Ghrita formulation, is traditionally indicated for neuropsychiatric conditions, including Apasmara, due to its Medhya, Rasayana, and Manasroga alleviating properties. With the rising interest in evidence-based validation of traditional therapies, a systematic review of available literature is essential to substantiate its clinical relevance. Aim: To critically review and analyze available classical and scientific evidence on the therapeutic potential of Maha-Panchagavya Ghrita in the management of Apasmara (epilepsy). Objectives: To compile classical Ayurvedic references regarding Maha-Panchagavya Ghrita and its indications in Apasmara. To review experimental and clinical studies evaluating its pharmacological actions relevant to epilepsy. To assess the probable mode of action based on Ayurvedic principles and modern scientific findings. To identify gaps in current research and suggest directions for future studies. Materials and Methods: A comprehensive search was conducted in electronic databases such as PubMed, AYUSH Research Portal, Google Scholar, and classical Ayurvedic compendia. Studies including clinical trials, experimental research, pharmacological investigations, and relevant Ayurvedic textual references were identified. Inclusion criteria comprised studies focusing on Maha-Panchagavya Ghrita in epilepsy or related neuropsychiatric disorders. Data were extracted, analyzed, and synthesized narratively. Results: Maha-Panchagavya Ghrita possesses neuroprotective, anti-convulsant, anxiolytic, and cognition-enhancing properties, as demonstrated by experimental and limited clinical studies. Classical references emphasize its role in pacifying aggravated Vata and Tama Dosha, which are key in the pathogenesis of Apasmara. However, robust high-quality clinical trials are sparse. Conclusion: Preliminary evidence indicates that Maha-Panchagavya Ghrita holds therapeutic potential in the management of Apasmara through its multifaceted pharmacological actions. Well-designed randomized controlled trials are warranted to establish its efficacy and safety profile in contemporary clinical practice.

Keywords: Maha-Panchagavya Ghrita, Apasmara, Ayurveda, Epilepsy, Evidence-Based Review, Medhya Rasayana.