Abstract

DESIGN AND EVALUATION OF PLUMBAGIN SOLID DISPERSION TABLETS: A STRATEGY FOR SOLUBILITY ENHANCEMENT

M. Vignesh*, Dr. G. Mariyappan, Dr. J. Karthi and Muthukumaran D.

Abstract

By utilising Poloxamer 188 as a solubility-enhancing carrier, the present research investigation sought to formulate and evaluate solid dispersion-based tablets of Plumbagin, a phytoconstituent that is poorly soluble in water. The solvent evaporation method was used for developing solid dispersions, which produced an amorphous product with greatly enhanced compressibility and flow characteristics, making it more suitable for tablet formulation. Solvent evaporation had been utilised to create solid dispersions, which produced an amorphous product with higher flow rates and compressibility. Preformulation and post-compression experiments (F1–F5) showed improved mechanical and physicochemical characteristics, such as homogenous drug content, quick disintegration, and suitable flow properties. Plumbagin's poor water solubility was confirmed by solubility experiments; it is most soluble in ethanol and methanol. Poloxamer 188 and Croscarmellose Sodium performed well together in the optimised formulation (F5), which showed the optimal balance of hardness, friability, disintegration time, and uniformity. Plumbagin's solubility and formulation issues were effectively resolved in this study, laying the groundwork for further investigations into enhancing its bioavailability, dissolution, and therapeutic effectiveness in oral solid dosage forms.

Keywords: Plumbagin, Solid dispersion, Poloxamer 188, Solubility enhancement, Tablet formulation.