Abstract

FORMULATION OPTIMIZATION AND EVALUATION OF PROCYCLIDINE HCL FLOATING TABLETS FOR ENHANCED GASTRIC RETENTION AND SUSTAINED RELEASE

S. Ranjith*, Dr. G. Mariyappan and Dr. J. Karthi

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Abstract

To determine how to prolong the stomach. retention and assure sustained medication release, the current study concentrated on developing and evaluating gastroretentive floating tablets of procyclidine HCl. Wet granulation was the technique employed to create five formulations (F1–F5), which included sodium bicarbonate as an effervescent agent, xanthan gum as a swelling agent, and HPMC K100M as the matrix-forming polymer. Following an extensive evaluation, it was determined that the tablets pre- and postcompression qualities - such as drug-excipient compatibility, flow characteristics, physical attributes, floating performance, and drug content uniformity—complied with accepted pharmacopeial standards. Effective floating competence has been established in vitro, with continuous buoyancy for up to 12 hours and lag periods ranging from 30 to 42 seconds. Higher polymer concentrations resulted in an increase in the swelling index, which helped with regulated medication release. The formulation which best fit the Korsmeyer-Peppas model, which identified a non-Fickian diffusion mechanism, occurred F4, which showed the most consistent release profile among the others. The formulation's resilience to stress was further validated by accelerated stability testing. In summary, the study successfully established a gastroretentive floating tablet method for Procyclidine HCl, which could be helpful manage Parkinsonism through decreasing the frequency of doses and improving patient compliance.

Keywords: Procyclidine HCl, Gastroretentive Drug Delivery System (GRDDS), Floating Tablets, Sustained Drug Release, HPMC K100M.