Abstract

DRUG DELIVERY VIA NANOSPONGES FOR THE MANAGEMENT OF HYPERTENSION

Chandrima Kanoongo*, Bhartendu Sharma, Sheetal Sharma

Abstract

Nanosponges have emerged as a highly promising and innovative approach to drug delivery, with the potential to revolutionize medicine. These nanoscale structures, composed of porous materials, including biocompatible polymers, present unique benefits for delivering therapeutic agents directly to targeted areas in the body. With their highly porous architecture, nanosponges can effectively encase various drug molecules, including small molecules, proteins, and nucleic acids. They are composed of three-dimensional networks or scaffolds filled with drugs and porous, insoluble nanoparticles, which can be either crystalline or amorphous and often have a spherical shape or exhibit swelling properties. Furthermore, the polarity and dimensions of the polymer mesh can be easily manipulated by changing the different type of cross-linker and the degree of cross-linking. These minuscule sponges, which are less than 1 μm in diameter, are capable of holding a diverse range of drugs. The encapsulation process not only safeguards the medication from deterioration, but additionally facilitates controlled release kinetics, enhancing therapeutic effectiveness while reducing potential side effects. Moreover, nanosponges can be specifically engineered with surface modifications to target certain tissues or cells, enabling accurate drug delivery to affected regions. The biocompatibility of nanosponges further highlights their suitability as drug carriers, ensuring ability to coexist with the biological environment and lowering the risk of adverse reactions. Additionally, their adaptability supports applications in a wide variety of therapeutic fields, such as oncology, infectious diseases, and regenerative medicine. In conclusion, nanosponges offer a compelling foundation for creating next-generation drug delivery systems. Their capacity to encapsulate, target, and regulate the release of therapeutic agents possess significant promise for enhancing the management of numerous medical conditions while minimizing side effects.

Keywords: Nanosponge, Hypertension, Controlled Release, Targeted Release, Novel drug delivery system.