Abstract

PREPARATION AND EVALUATION OF PRONIOSOMAL ROSUVASTATIN GEL FOR TRANSDERMAL DELIVERY

Dr. T. Mangilal*, K. S. K Rao Patnaik, M. Satish Kumar, L. Thirupathi, I. Nagaraju, P. Veeresh Kumar

Abstract

The main aim of the current study was to formulate and evaluate a stable proniosomal gel using rosuvastatin to avoid problems associated with conventional delivery system such as limited permeation, low dissolution and bioavailability and also to improve bioavailability and hypocholesteromic effect in blood vessels.The preformulation studies were performed to know the physico-chemical and mechanical properties of rosuvastatin encapsulated in proniosomes. The drugexcipient compatability studies were conducted to characterize the drug rosuvastatin present in proniosomes. Eight formulations were taken as trial formulations for optimizing the final formulation. Finally, optimized PGR1 formulation has been selected as the final formulation containing Span 80 with Soya. In-vitro release studies, drug content and drug entrapment studies were performed to evaluate the optimized formulation. FTIR spectra of rosuvastatin indicates there was no chemical alteration of the drug characteristics. The calibration range of rosuvastatin was found to be 5-35μg/ml at λmax of 248 nm. The percentage drug content of optimized formulation was found to be 96.7%, shown higher % drug entrapment i.e.92.8%. In vitro drug release of PGR1 was found to be 96.3% for 24hr that reveals sustainability of drug release to improve bioavailability of rosuvastatin in systemic circulation. Finally, it was concluded that the Proniosomal rosuvastatin gel was found to be a stable alternative transdermal delivery approach to enhance the bioavailability with hypocholestrolemic effect.

Keywords: The main aim of the current study was to formulate and evaluate a stable proniosomal gel using rosuvastatin to avoid problems associated with conventional delivery system such as limited permeation, low dissolution and bioavailability and also to improve